An ancient and evil extraterrestrial slime that was buried in a remote Colorado canyon eons ago is returning to life. While the military and various government agencies and players trip over themselves to control it, it falls on the "Watchdogs," an aging group of military veterans who live at an old diner watching over the canyon, to stop the menace. As the slime grows in power and turns more locals into glowing, vomit-spewing zombies, the story grows wilder and wilder until its gooey climax.